Aditya Choudhary et al. Froin Syndrome. 1Aditya Choudhary, 2Manoj K Goyal, 3Manish Modi, 4Kanchan K Mukherjee, 5Chirag K Ahuja, 6Vivek Lal. Georges Froin (–), a French physician practising at the turn of the century, was the first to describe the xanthochromia and marked coagulation of. Froin Syndrome is characterized with xanthochromic CSF, high CSF protein content, complete blockage of CSF circulation. We reported our case of Froin.

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Pseudo-Froin’s syndrome, xanthochromia with high protein level of cerebrospinal fluid

Introduction Georges Froin reported in that xanthochromic cerebrospinal fluid CSF and coagulation caused meningeal irritation. Comparative values of CSF-cholesterol and CSF-triglycerides along with other biochemical parameters in neurological disorders. Support Center Support Center. Froin Syndrome was suggested according to these findings. In the case discussed here, the patient had suffered from year paraplegia with newly-developed urinary bladder cancer and showed abnormal CSF characteristics at spinal anesthesia.

View large Download slide. Spectrophotometric analysis of xanthochromia is recommended for distinction between a traumatic spinal tap and a true intracranial bleed in cases when a yellow color of the CSF is observed.

Normal microbiology results have led us to exclude acuute purulent meningitidis. Nowadays, a magnetic resonance imaging is used for identification of CSF flow obstruction.


We obtained cranial and spinal MRI in order to support the diagnosis.

Incidental Finding of Froin Syndrome during Spinal Anesthesia in a 72-Year-Old Patient

CSF biochemistry results of the patient were consistent with Froin syndrome. Microbiology results were normal. These findings were radiologically consistent with extradural spinal mass.

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Guidelines Upcoming Special Issues. High protein contents of the CSF have syndeome causes such as bacterial, cryptococcal, or tuberculous meningitis, as well as non-infectious causes, such as subarachnoid hemorrhage, central nervous system CNS vasculitis, CNS neoplasm, and autoimmune disease.

No specific problems such as headache, reflex tachycardia, or sweating were observed in the perioperative period.

Pseudo-Froin’s syndrome, xanthochromia with high protein level of cerebrospinal fluid

No motor or sensory abnormalities were found in the upper chest or upper extremities. Adams RD, Victor M editors. Pharmaceutical Sciences Journals Ann Jose ankara escort.

Published online Dec However, protein and glucose in the CSF are non-specific and not significant, and other parameters are investigated for the diagnosis and prognosis of neurologic disorders.


Comparison and outcome analysis of patients with apical and non-apical takotsubo cardiomyopathy. Ann Jose ankara froln. His paper was published in Gazette des hopitaux in [ 1 ].

On physical examination, the patient was afebrile with paraparesis, his knee and ankle reflexes were absent, and a sensory level could not be established. Please review our privacy policy. From Wikipedia, the free encyclopedia.

J Pain Relief 3: The patient underwent extensive diagnostic testing in search of a primary tumour outside the central nervous system. It is caused by meningeal irritation e. Interruption of the spinal canal and stagnation of the CSF by a neoplastic mass or herniated disc contribute to the sequestered CSF circulation and the high protein content of the CSF.

Retrieved from ” https: Please introduce links to this page from related articles ; try the Find link tool for suggestions. We reported our case of Froin Syndrome, a quite rare entity, with its radiologic features and characteristics of CSF biochemistry in the light of literature.