Wirus kleszczowego zapalenia mózgu (Tick-borne encephalitis virus – TBEV) stanowi czynnik etiologiczny groźnego sezonowego schorzenia ośrodkowego. Wśród nich najczęstsze były choroby przenoszone przez kleszcze (93%) – borelioza (85,8%) i kleszczowe zapalenie mózgu (7,2%). Wiek rolników, u których. KLESZCZOWE ZAPALENIE MÓZGU – AKTUALNE DANE EPIDEMIOLOGICZNE. Tytuły w innych językach: TICK BORN ENCEPHALITIS – CURRENT.
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Annales Academiae Medicae Silesiensis. Etiopathogenesis of tick-borne encephalitis TBE.
The tick-borne encephalitis virus TBEV is an etiological agent of tick-borne encephalitis TBEa serious seasonal disease of the central nervous system transmitted by ticks. Within TBEV, there are three subtypes, and their geographic scopes are closely related to the tick species mostly Ixodes ricinus and I.
Zzapalenie distribution range of ticks, and hence TBEV, has broadened in recent years and new endemic foci of the virus are emerging. The life cycle of TBEV in the environment is infl uenced by the interactions between the virus, vector and reservoir. The population density of ticks and their hosts in a given terrain determines the circulation of the virus in this area.
The course of infections caused by certain TBEV subtypes shows substantial diff erences in the clinical picture.
Occupational diseases among farmers in Poland.
Typical TBEV infection has a biphasic course. There are several factors aff ecting the course of the infection. Type I interferons play a major role in controlling viral replication. Dendritic cells, the important producers of interferon, are the primary target for TBEV in the early phase of the infection.
Furthermore, TBEV is a neurotrophic virus causing the development of infl ammation and destruction of neurons and immunopathological eff ects. It is believed that the immune system, especially cytotoxic T cells, plays a key role in the destruction of neurons, and to a lesser extent, the direct lysis of cells infected with TBEV. The immune response directed at the elimination of TBEV infection paradoxically contributes to the exacerbation of the disease. So far, active vaccination is the only eff ective method of TBE prevention.
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Occupational diseases among farmers in Poland.
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